The competition started on 17 August 2021 with the preliminary round and concluded with the final on 21 May 2022.
[1][2] The following teams qualified for the competition: 10 clubs from the Divizia B entered this round.
Teams that finished higher on the league in the previous season played their ties away.
In a match, the home advantage was granted to the team from the lower league.
The "home" team (for administrative purposes) was determined by an additional draw held on 28 April 2022.