The 2021–22 Moldovan National Division (Romanian: Divizia Națională) was the 31st season of top-tier football in Moldova.
The winners of the league this season earned a spot in the first qualifying round of the 2022–23 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2022–23 UEFA Europa Conference League.
Additionally, Speranța Nisporeni were expelled from the league, and thus ending their six-year stay in the top flight.
The following table represents the teams game results in each round.
The "home" team (for administrative purposes) was determined in a draw held on 19 May 2022.