The 2021–22 Murray State Racers men's basketball team represented Murray State University in the 2021–22 NCAA Division I men's basketball season.

The Racers, led by seventh-year head coach Matt McMahon, played their home games at the CFSB Center in Murray, Kentucky as members of the Ohio Valley Conference.

They received the conference's automatic bid to the NCAA tournament as the No.

[2] On March 28, the school named former Murray State and Iowa State head coach Steve Prohm the team's new head coach.

In the OVC tournament, they were defeated by Jacksonville State in the quarterfinals.