The 2021–22 season was the 35th season in the existence of Nîmes Olympique and the club's first season back in the second division of French football.

In addition to the domestic league, Nîmes participated in this season's edition of the Coupe de France.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Source: Soccerway Source: Ligue 2 The league fixtures were announced on 25 June 2021.