The 2021–22 NCAA Division I men's basketball season began on November 9, 2021 and concluded on March 13, 2022.

The 2022 NCAA Division I men's basketball tournament culminated the season and began on March 15 and concluded on April 4 with the championship game at the Caesars Superdome in New Orleans, Louisiana.

Five NCAA Division II schools started transitions to D-I after the season.

Each of the 32 Division I athletic conferences ended its regular season with a single-elimination tournament.

Source for additional stats categories For this list, an "upset" is defined as a win by a team seeded 5 or more spots below its defeated opponent.