The 2021–22 NC State Wolfpack women's basketball team represented North Carolina State University during the 2021–22 NCAA Division I women's basketball season.

The Wolfpack were led by ninth-year head coach Wes Moore and played their home games at Reynolds Coliseum as members of the Atlantic Coast Conference.

As the first seed in the ACC tournament, they earned a bye to the Quarterfinals where they defeated ninth seed Florida State, then they defeated fifth seed Virginia Tech in the Semifinals, and they won the Final versus seven seed Miami to win their third straight tournament title.

As champions, they earned the ACC's automatic bid to the NCAA tournament where they were the first seed in the Bridgeport Region.

It was NC State's sixth title in school history.