The 2021–22 NK Osijek season was the club's 108th season in existence and the 31st consecutive season in the top flight of Croatian football.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Total Spending: €4,650,000 Total Income: €5,200,000 Net Income: €550,000 Last updated: 22 May 2022 Source: Soccerway Last updated: 22 May 2022.

Source: Prva HNL Updated 22 May 2022 Source: Competitive matches Source: Competitive matches