[1] This season saw a return to the abridged format whereby the fourteen clubs are divided into two groups of seven teams each whereafter a "Super Six" tournament will decide the league champions.
Bayelsa Queens won their 5th NWFL Premiership title after emerging champions of the Super Six tournament.
[3] Naija Ratels and Adamawa Queens were promoted to the top-flight after winning the NWFL Championship play-offs; the latter having failed to compete the previous season due to late licensing and registration.
The top six teams at the end of the regular season engaged each other in a round-robin playoff also known as the Super Six between 16 and 22 May in order to decide the league champion and representative at the 2022 CAF Women's Champions League.
All matches are played at the Samuel Ogbemudia Stadium and UNIBEN Sports Complex in Benin City.