The 2021–22 National League 2 North was the twelfth season (34th overall) of the fourth tier (north) of the English domestic rugby union competitions since the professionalised format of the second division was introduced.

Hull were crowned champions on 23 April 2022, when they played their last but one match of the season at home to local rivals Hull Ionians, beating them with a final minute try, 31–29 in front of a crowd of 950.

Owing to the reorganisation of the national leagues, there was no play-off match and Sedgley Park continued to play at this level.

Huddersfield (15th) and Harrogate (16th) also continued to play at this level, due to the increase of tier 4 leagues from two to three.

There is one promotion place and owing to the reorganisation of tier three and four divisions, there is no relegation.