The Cornhuskers were led by third-year head coach Fred Hoiberg and played their home games at Pinnacle Bank Arena in Lincoln, Nebraska as members of the Big Ten Conference.

[1] Due to COVID-19, the NCAA ruled that the 2020–21 season would not count against the eligibility of any competitor in any of the organization's winter sports, including basketball.

This in turn meant that all players active in the 2020–21 season, regardless of their academic classification, could return in 2021–22.

On November 13, 2020, five-star shooting guard Bryce McGowens committed to Nebraska.

[3] Wilhelm Breidenbach,[4] Oleg Kojenets,[5] Quaran McPherson,[6] and Keisei Tominaga[7] rounded out the 2021 class.