The 2021–22 Nedbank Cup was the 2021–22 edition of South Africa's premier knockout club football (soccer) competition, the Nedbank Cup.
Mamelodi Sundowns won the competition after defeating Marumo Gallants in the final.
[1] Eight teams from the SAFA Second Division (called the ABC Motsepe League for sponsorship reasons) qualify for the round of 32.
One team from each of the nine provinces is selected, with two teams drawn to play each other in a knockout to reduce the number to eight.
The nine teams from the provinces were: Mathaithai and Mikhado were selected to play each other, with Mathaithai winning the playoff.