The 2021–22 Nemzeti Bajnokság I (also known as 2021–22 OTP Bank Liga), also known as NB I, was the 123rd season of top-tier football in Hungary.
The league was officially named OTP Bank Liga for sponsorship reasons.
Diósgyőr and Budafok finished the 2020–21 Nemzeti Bajnokság I in the last two places and thus were relegated to NB II division.
The two relegated teams were replaced with the top two teams in 2020–21 Nemzeti Bajnokság II, champion Debrecen and runner-up Gyirmót, each having the required licence for top-division play.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.