The 2021–22 Nemzeti Bajnokság II (also known as 2021–22 Merkantil Bank Liga) was Hungary's 71st season of the Nemzeti Bajnokság II, the second tier of the Hungarian football league system.
The season began in July 2021.
The following teams have changed division since the 2020–21 season.
Although Iváncsa KSE finished 1st in the 2020-21 Nemzeti Bajnokság III Centre group, Kecskeméti TE were promoted.
Following is the list of clubs competing in the league this season, with their location, stadium and stadium capacity.