[2] Before the season, the Devils lost Nathan Bastian to the Seattle Kraken in the 2021 NHL Expansion Draft,[3] but reacquired him in on November 25, 2021.
[4] On March 31, 2022, following an 8–1 loss to the Boston Bruins, the Devils were eliminated from playoff contention for the fourth consecutive season.
[8] The Devils' game against the New York Islanders on October 7, 2021, was cancelled due to a power outage at Prudential Center in Newark, New Jersey.
[16] However, on December 22, the NHL announced that its players would not participate in the 2022 Winter Olympics due to the ongoing COVID-19 pandemic.
Below are the New Jersey Devils' selections at the 2021 NHL Entry Draft, which was held on July 23 and 24, 2021, in a remote format, with teams convening via videoconferencing, and Commissioner Gary Bettman announcing selections from the NHL Network studios in Secaucus, New Jersey.