The 2021–22 New Mexico Lobos men's basketball team represented the University of New Mexico during the 2021–22 NCAA Division I men's basketball season.

The Lobos were led by first-year head coach Richard Pitino and played their home games at The Pit as members of the Mountain West Conference.

In a season limited due to the ongoing COVID-19 pandemic, the Lobos finished the 2021–21 season 6–16, 2–15 in Mountain West play to finish in last place.

In the Mountain West tournament, they lost in the first round to Fresno State.

Prior to the end of the season, the school announced that Paul Weir would not return as head coach.