[3] Before the season, the Islanders lost Jordan Eberle to the Seattle Kraken in the 2021 NHL Expansion Draft.
[4] On April 17, 2022, the Islanders were eliminated from playoff contention following a 4–2 loss to the Toronto Maple Leafs.
[10] Notes: a Game was played at Webster Bank Arena in Bridgeport, Connecticut.
[17] However, on December 22, the NHL announced that its players would not participate in the 2022 Winter Olympics due to the ongoing COVID-19 pandemic.
Below are the New York Islanders' selections at the 2021 NHL Entry Draft, which was held on July 23 and 24, 2021, in a remote format, with teams convening via videoconferencing, and Commissioner Gary Bettman announcing selections from the NHL Network studios in Secaucus, New Jersey.