The 2021–22 Nicholls Colonels men's basketball team represented Nicholls State University in the 2021–22 NCAA Division I men's basketball season.

The Colonels, led by fourth-year head coach Austin Claunch, played their home games at Stopher Gymnasium in Thibodaux, Louisiana as members of the Southland Conference.

They lost in the semifinals of the Southland tournament to Texas A&M Corpus-Christi.

1 seed who didn’t win their conference tournament, they received an automatic bid to the National Invitation Tournament where they lost in the first round to SMU.

In the Southland tournament, they defeated Northwestern State in the semifinals,[1] before falling to Abilene Christian in the championship game.