The Cobblers announced their first pre-season friendly against Birmingham City, as part of the club's open day.

Source: [citation needed] Northampton Town's fixtures were announced on 24 June 2021.

[8] Win Draw Loss Postponed Northampton were drawn at home to Cambridge United in the first round.

[12][13] Cobblers were drawn into Southern Group D alongside Brighton & Hove Albion U21s, Forest Green Rovers and Walsall.

Win Draw Loss At the end of the season, Northampton's annual award ceremony, including categories voted for by the players and backroom staff, the supporters, will see the players recognised for their achievements for the club throughout the 2021–22 season.