The Panthers, led by 16th-year head coach Ben Jacobson, played their home games at the McLeod Center in Cedar Falls, Iowa as members of the Missouri Valley Conference.

With a win over Loyola on February 26, 2022, the Panthers won the regular season MVC championship.

They defeated Illinois State in the quarterfinals of the MVC tournament before losing in the semifinals to Loyola.

Green played in only three games before he underwent hip surgery and missed the remainder of the season.

However, they were forced to forfeit their quarterfinal game against Drake due to a positive COVID test and subsequent contact tracing within the UNI program.