The 2021–22 Northern Iowa Panthers women's basketball team represented the University of Northern Iowa during the 2021–22 NCAA Division I women's basketball season.

The Panthers were led by head coach Tanya Warren in her fifteenth season, and played their home games at the McLeod Center as a member of the Missouri Valley Conference (MVC).

The Panthers finished the 2020–21 season with a 17–13 record, including 11–7 in MVC play.

They received a bid to the 2021 Women's National Invitation Tournament, where they advanced to the Final Four.

[1] Sources: Roster Last update: March 15, 2022 Source:[2]