2021–22 Northern Premier League

The Premier Division comprised the same set of 22 teams which competed in the aborted competition the previous season.

Division One East comprised 19 teams, with a vacancy left due to the withdrawal of Droylsden in the previous campaign.

Semi-finals Final Seven clubs at Step 3, all four fourth-from-bottom teams and those placed third-from-bottom that are the top three on a points per game (PPG) basis, were reprieved from relegation.

[6] The remaining six teams contested one-off matches with six runners-up from Step 5 that had the fewest PPG at the end of the 2021–22 season.

[3] The final points-per-game ranking of the 3rd-from-bottom-placed teams in Step 4 divisions was also as follows: Source: [5] For the second successive season, it was announced to member clubs that the League Challenge Cup was cancelled due to any further fixture disruptions that might have occurred during the COVID-19 pandemic.