The 2021–22 Oklahoma State Cowboys basketball team represented Oklahoma State University during the 2021–22 NCAA Division I men's basketball season.

The team was led by fifth-year head coach Mike Boynton, and played their home games at Gallagher-Iba Arena in Stillwater, Oklahoma as a member of the Big 12 Conference.

On November 3, 2021, the NCAA ruled Oklahoma State ineligible for postseason play for the season due to player receiving improper benefits.

They defeated West Virginia and Baylor in the Big 12 tournament before losing to Texas in the championship game.

Sources: Roster The Big 12 allows all 10 teams to participate in the Big 12 Tournament to determine the conference's automatic bid to the NCAA Tournament with every team being guaranteed at least one game.