The 2021–22 Old Dominion Monarchs men’s basketball team represented Old Dominion University in the 2020–21 NCAA Division I men's basketball season.

The Monarchs, led by ninth-year head coach Jeff Jones, played their home games at Chartway Arena in Norfolk, Virginia as members of the East division of Conference USA.

On October 27, 2021, Old Dominion announced that the season would be the last for the team in C-USA and that they would join the Sun Belt Conference on July 1, 2022.

[1] In a season limited due to the ongoing COVID-19 pandemic, the Monarchs finished the 2020–21 season 15–8, 11–5 in C-USA play to finish in second place in East division.

They lost in the quarterfinals of the C-USA tournament to North Texas.