Olympiacos participated in the Greek Super League winning their 47th title (3rd in a row), finishing 19 points ahead of PAOK who came second.

During the season Pedro Martins became the longest-serving Piraeus coach in a single term.

[1] The season covers the period from July 2021 to late May 2022.

Total Income: €11.80M Net Income: €0.42M Win Draw Loss Last updated: 17 May 2022 Source: Competitions Last updated: 17 May 2022.

The knockout round play-offs draw was held on 13 December 2021.