The 2021–22 Oral Roberts Golden Eagles women's basketball team represented Oral Roberts University in the 2021–22 NCAA Division I women's basketball season.

The Golden Eagles, led by tenth-year head coach Misti Cussen, competed in the Summit League.

They played home games in Mabee Center in Tulsa, Oklahoma.

They played the previous year's champion South Dakota in the quarterfinals but lost 66–89.

Sources: The Summit League Preseason poll and other preseason awards was released on October 12, 2021 with the Golden Eagles selected to finish in sixth place in the Summit League.