The Ducks, led by 12th-year head coach Dana Altman, played their home games at Matthew Knight Arena as members of the Pac–12 Conference.

They were invited in the NCAA Tournament as a at-large bid where they moved on because VCU had Coronavirus.

They beat Iowa in the second round before losing to PAC-12 member USC in the Sweet Sixteen.

Note that all players in the 2020–21 season, regardless of their classification, had the option to return to the program.

Due to COVID-19 impacts, the NCAA declared that the 2020–21 season would not count against the athletic eligibility of any student-athlete in any of the organization's winter sports, including basketball.