In addition to the domestic league, PEC Zwolle participated in this season's editions of the KNVB Cup.
On 11 May, PEC Zwolle descended to the second division for the first time since the 2011–12 season.
[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Players may hold more than one non-FIFA nationality.
Source: Eredivisie The league fixtures were announced on 11 June 2021.