[1] On April 28, 2021, the league announced that it was planning to double the salary cap of every franchise to $300,000, based on projections of financial stability for the seventh season.

[6] On May 10, the NWHL announced the sale and transfer of ownership of the Connecticut Whale to Shared Hockey Enterprises (SHE), LLC, led by Tobin Kelly.

[7] The Whale became the first of the four founding teams to be sold to outside ownership after the league's October 2020 announcement of its transition to joint venture models.

[8] The NWHL finished selling its league operated teams to independent ownership with the sale of the Buffalo Beauts and Minnesota Whitecaps to a joint partnership of NLTT Ventures, LLC, and Top Tier Sports on June 28, 2021.

The Isobel Cup playoffs were held in the Tampa Bay area at AdventHealth Center Ice in Wesley Chapel, Florida.