The 2021–22 NBL season was the 41st season for the Perth Wildcats in the NBL.

The 2022 season marks the first time in 35 years that the Perth Wildcats have not qualified for the finals, having last failed to do so in 1986.

[1] Note: Flags indicate national team eligibility at FIBA-sanctioned events.

Players may hold other non-FIBA nationalities not displayed.

Total Rounds 2 weeks Total Games 21 games Updated to match(es) played on 24 April 2022.