[2] On March 29, 2022, the Flyers were eliminated from playoff contention, with a 4–1 loss to the Minnesota Wild.
[5] Two days after playing in his 1,000th NHL game, captain Claude Giroux was traded to the Florida Panthers on March 19.
The Flyers 4–3 loss to the New York Islanders on January 25 featured two records being broken.
Notes: Below are the Philadelphia Flyers' selections at the 2021 NHL entry draft, which were held on July 23 to 24, 2021.
It was held virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.