The 2021–22 Pittsburgh Panthers men's basketball team represented the University of Pittsburgh during the 2021–22 NCAA Division I men's basketball season.

The Panthers were led by fourth-year head coach Jeff Capel and played their home games at the Petersen Events Center in Pittsburgh, Pennsylvania as members of the Atlantic Coast Conference.

As the twelfth seed in the ACC tournament, they lost to thirteenth seed Boston College in the First Round.

In a season limited due to the ongoing COVID-19 pandemic, the Panthers finished the 2020–21 season 10–12, 6–10 in ACC play to finish in 12th place.

They lost to Miami in the first round of the ACC tournament.