[2] On March 27, 2022, the Penguins defeated the Red Wings, 11–2, marking the first time the team has scored 11 goals in a game since November 16, 1993.
[3] On April 14, 2022, the Penguins clinched their 16th consecutive playoff appearance after a 6–3 win over the New York Islanders.
Before the season, the Penguins shipped left wing Brandon Tanev off to play for the Seattle Kraken.
Notes: Below are the Pittsburgh Penguins' selections at the 2021 NHL Entry Draft, which were held on July 23 to 24, 2021.
It was held virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.