Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Plymouth Argyle announced they will play friendlies against Plymouth Parkway,[2] Bristol Rovers,[3] Swansea City,[4] Middlesbrough,[2] Tavistock,[2][5] Bristol City[2] and Torquay United[6] as part of their pre-season schedule.

Source: [citation needed] Plymouth's fixtures were announced on 24 June 2021.

[15][16] Argyle were drawn into Southern Group F with Arsenal U21s, Newport County and Swindon Town.

[17][18] The group stage fixtures were confirmed on 3 August.