The defending champions, Everton, who won the 2018–19 competition, were eliminated in the group stage.
[1] The previous two editions of the competition were cancelled, or not completed due to the COVID-19 pandemic in the United Kingdom.
3 teams, Mansfield Town, Salford City, and Stevenage participated for the very first time in the competition this season.
[40] The final details were announced on 6 May 2022, with West Bromwich Albion being picked as the home team.
[41] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.