The season began on 16 July 2021 and ended on 29 May 2022, with a winter break between early December 2021 and late February 2022.
[1] A total of 12 teams contested in the league, including 9 sides from the 2020–21 season and three promoted from each of the second-level leagues, Posušje, Rudar Prijedor and Leotar, replacing relegated sides Mladost Doboj Kakanj, Olimpik and Krupa.
[2] Note: Flags indicate national team as has been defined under FIFA eligibility rules.
The table lists the positions of teams after each week of matches.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.