The reigning champions entering the season were Harlequins who claimed their 2nd title after defeating Exeter Chiefs in the 2021 final.

Due to changes to the global rugby calendar implemented in 2020 and the COVID-19 pandemic causing a moratorium to be placed on relegation last season, the tournament features thirteen teams and will include an extra four rounds.

A brief summary of the changes are: For the first time since the 2002–03 Premiership Rugby season, all teams from the previous season will compete in the league together with Saracens who were promoted from the 2020–21 RFU Championship after an absence of one year, thus making a thirteen team league.

As in previous seasons, the top four teams in the Premiership table, following the conclusion of the regular season, contest the play-off semi-finals in a 1st vs 4th and 2nd vs 3rd format, with the higher ranking team having home advantage.

Player of the Match: Jasper Wiese (Leicester Tigers) Touch judges: Luke PearceChristophe Ridley Television Match Official: Tom Foley Note: Flags to the left of player names indicate national team as has been defined under World Rugby eligibility rules, or primary nationality for players who have not yet earned international senior caps.