This was the fifth Primeira Liga season to use video assistant referee (VAR).

Estoril, Vizela and Arouca joined as the promoted clubs from the 2020–21 Liga Portugal 2.

They replaced Farense, Nacional and Rio Ave, which were relegated to Liga Portugal 2 the previous season.

This season saw the return of full capacity crowds, after the final third of the 2019–20 and the entirety of the 2020–21 seasons were held with limited or no attendance due to the restrictions caused by the COVID-19 pandemic in Portugal.

[5] Porto secured their 30th league title with one match remaining, following a 1–0 away victory over rivals Benfica on 7 May 2022.