The 2021–22 Primera Divisió was the 27th season of top-tier football in Andorra.
[2] Inter Club d'Escaldes were the defending Primera Divisió champions.
[3] Penya Encarnada were relegated from the Primera Divisió after finishing in last place the previous season.
The eight clubs played each other three times for a total of twenty-one matches each in the regular season.
[1] Regular season records are carried over to championship and relegation rounds.