The 2021–22 Primera División Femenina de Fútbol was the 34th edition of Spain's highest women's football league, the 21st since the inception of the Superliga Femenina.
The league began on 5 September 2021 and finished on 15 May 2022.
They defended the title with a perfect season (30 wins in 30 matches).
The table lists the positions of teams after each week of matches.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.