The 2021–22 Primera División de El Salvador, also known as the Liga Pepsi, is the 23rd season and 45th and 46th Primera División tournament, El Salvador's top football division, since its establishment of an Apertura and Clausura format.
Should the final of both tournaments features the same two teams, the semi-finalist with the better aggregate record will qualify for CONCACAF League.
Platense Municipal Zacatecoluca was promoted to the Primera División in June 2021 after defeating Real Destroyer in a playoff match by a score of 2–1.
The aggregate table is used to determine seeding for the CONCACAF Tournaments and relegation to the segunda division.
Isidro Metapán Jocoro Limeño Once Deportivo Platense Santa Tecla