The team was led by 11th-year head coach Ed Cooley, and played their home games at Dunkin' Donuts Center in Providence, Rhode Island as a member of the Big East Conference.

[1] The Friars defeated Butler in the quarterfinals of the Big East tournament before losing to Creighton in the semifinals.

They defeated South Dakota State and Richmond to advance to the Sweet Sixteen.

6 seed in the Big East tournament, they lost to DePaul in the first round.

[6] An additional game against Georgetown was originally canceled[7] and then later rescheduled for January 20, 2022.