[1][2] In September 2021, the Pakistan Cricket Board (PCB) confirmed the fixtures for the tournament,[3] with the full schedule being announced the following month.

[6][7] On 7 November 2021, the PCB announced that fourth round match between Central Punjab and Sindh would be played with the pink ball, along with the final of the tournament.

[8] The first result other than a draw came in the fourth round of the tournament, when Southern Punjab beat Northern by ten wickets.

[9] In the same round, Ahsan Ali became the ninth batsman to score a triple century in the Quaid-e-Azam Trophy,[10] when he made 303 not out in Sindh's match against Central Punjab.

[14] In the tenth round of fixtures, Mohammad Huraira of Northern scored his maiden triple century in first-class cricket.