The 2021–22 season was the 82nd season in the existence of RKC Waalwijk and the club's third consecutive season in the top flight of Dutch football.

In addition to the domestic league, RKC Waalwijk participated in this season's editions of the KNVB Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: Eredivisie The league fixtures were announced on 11 June 2021.