The 2021–22 Radford Highlanders men's basketball team represented Radford University in the 2021–22 NCAA Division I men's basketball season.

The Highlanders, led by first-year head coach Darris Nichols, played their home games at the Dedmon Center in Radford, Virginia as members of the Big South Conference.

The Highlanders finished the season 11–18, 7–9 in Big South play, to finish in a tie for third place in the North Division.

[1] In the Big South tournament, they were defeated by North Carolina A&T in the first round.

[3] They lost to Campbell in the semifinals of the Big South tournament.