[10] On the same day, young goalkeeper Coniah Boyce-Clarke joined Bath City to train with and feature in the forthcoming pre-season games.

[14] On 28 July, Nahum Melvin-Lambert returned to St Patrick's Athletic on loan for the second half of the 2021 League of Ireland Premier Division season.

[19] On the same day, young academy defender Jack Senga joined Maidenhead United on a work experience loan deal.

[22] On 30 August, Reading announced the signing of Scott Dann to a one-year contract, after he'd left Crystal Palace in the summer, whilst Danny Drinkwater join on a season-long loan from Chelsea later in the same day.

[36] On 8 January, Reading suffered a shock 2–1 defeat to National League North side Kidderminster Harriers in the FA Cup.

[39] On 15 January, Reading were defeat 2-1 by away at Middlesbrough, with Andy Carroll scoring the goal in what was he last appearance for the club, with his short-term contract ending the same day.

[43] On 27 January, Reading announced that their postponed home fixture against Stoke City, originally scheduled for 15 February, had been rearranged for 5 April.

[44] On the same day, Reading's away trip to Peterborough United, scheduled for 15 February, had been pushed back 24hours after it was picked to be shown live on Sky Sports.

[52] On 9 March, Paul Ince confirmed that Karl Hein had returned to Arsenal after a finger injury had ruled him out for the remainder of the season.

[59] On the final day of the season, whilst the first-team faced Luton Town at Kenilworth Road, Readings U23 team won the 2021–22 Berks & Bucks Senior Cup, defeating Ascot United with goals from Ajani Giscombe, Imari Samuels and a Nahum Melvin-Lambert brace.

Pro terms where also offered to Hamid Abdel Salam, Sam Paul, Matthew Rowley and Benjamin Purcell, with Ajani Giscombe, Harvey Maudner and David Nyarko also having their contracts extended for an additional year.

[63] On 15 June, the EFL released the Retained List for each club, which confirmed contract renewals for Jahmari Clarke, Tyrell Ashcroft, Louie Holzman, Harvey Collins, Hamid Abdel-Salam, Sam Paul, Matt Rowley, Benjamin Purcell, Jeriel Dorsett and Kian Leavy.

[67] On 24 June, Reading announced that Mamadi Camará, Rashawn Scott, Nelson Abbey, Matt Rowley, Sam Paul, Benjamin Purcell and Claudio Osorio had all signed new contracts with the club for the 2022-23 season.

[120] Reading's second pre-season friendly was confirmed on 8 June, a behind-closed door meeting with Charlton Athletic at the Madejski Stadium on 24 July.

[121] On 21 June, Reading confirmed their first pre-season friendly would be a behind-closed-doors match against Lincoln City on 10 July at their Bearwood Park Training Ground.