The winners, Lincoln Red Imps qualified for the 2022–23 UEFA Champions League, due to finishing first in the 2021–22 Gibraltar National League, so the fourth-placed team, Bruno's Magpies qualified for the 2022–23 UEFA Europa Conference League instead.
Lincoln Red Imps are the defending champions,[1] who also won this edition by defeating Bruno's Magpies in the final, 2–1, after scoring two late goals in the 89th and 90+1st minute to come back from a 1–0 deficit.
The draw for the first round of this season's tournament was held on 7 January 2022.
Bruno's Magpies received a bye to the quarter-finals by virtue of winning the GFA Challenge Trophy last season.
[2] After the draw, 3 more teams received byes to the next round: Europa Point, Lions Gibraltar and Mons Calpe.