In addition to the domestic league, Lazio participated in this season's editions of the Coppa Italia and the UEFA Europa League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[17] The draw for the group stage was held on 27 August 2021.

The knockout round play-offs draw was held on 13 December 2021.