The 2021–22 season was SV Darmstadt 98's 124th season in existence and the club's fifth consecutive season and 22nd season overall in the 2.

Bundesliga, the second tier of German football.

The club also participated in the DFB-Pokal.

Darmstadt 98 finished the 2020–21 season in 7th place, 11 points below the automatic promotion places and 13 points below the promotion play-off place.

[1] Manager Markus Anfang left the club at the end of the previous season and was replaced by Torsten Lieberknecht in June 2021.