The 2021–22 Saint Francis Red Flash men's basketball team represented Saint Francis University in the 2021–22 NCAA Division I men's basketball season.

The Red Flash, led by eleventh-year head coach Rob Krimmel, played their home games at the DeGol Arena in Loretto, Pennsylvania as members of the Northeast Conference.

In a season limited due to the ongoing COVID-19 pandemic, the Red Flash finished the 2020–21 season 6–16, 5–13 in NEC play to finish in a tie for ninth place.

Due to complications caused by the pandemic, only the top four teams were eligible to participate in the NEC tournament.

[1] Roster Last update: November 30, 2021 NEC COVID-19 policy provided that if a team could not play a conference game due to COVID-19 issues within its program, the game would be declared a forfeit and the other team would receive a conference win.