The 2021–22 Samford Bulldogs men's basketball team represented Samford University in the 2021–22 NCAA Division I men's basketball season.

The Bulldogs, led by second-year head coach Bucky McMillan, played their home games at the Pete Hanna Center in Homewood, Alabama as a member of the Southern Conference.

3 seed in the SoCon tournament, they defeated UNC Greensboro before losing to Furman in the semifinals.

In a season limited due to the ongoing COVID-19 pandemic, the Bulldogs finished the 2020–21 season 6–13, 2–9 in SoCon play to finish in last place.

They lost to Mercer in the first round of the SoCon tournament.